Introduction to mass spectrometry imaging
Blog series
This series provides an introduction to the field of mass spectrometry imaging, ranging from important characteristics of the instruments up to the main types of analytes and their applications.
Posts in this series
MSI hardware part 1: ionization techniques
Are you confused by all the acronyms used in mass spectrometry imaging? In this series of blogs, we hope to provide you with a brief introduction and explanation of some of the different things you might want to know about the technology, starting with the hardware. In this post, we will describe the main ionization techniques and tackle some of those pesky acronyms in the process.
By Alice Ly on May 13, 2021
Read time: 6 minutes
MSI hardware part 2: mass analyzers
In continuation of our quest to elucidate technical terms in mass spectrometry, this post describes the most commonly used mass analyzers in imaging, namely time of flight (TOF), Orbitrap and Fourier transform ion cyclotron resonance (FTICR).
By Alice Ly on June 14, 2021
Read time: 6 minutes
MSI applications part 1: glycans
In this blog post we introduce you to the wonderful world of glycans, an interesting analyte for which mass spectrometry imaging is proving to be particularly powerful.
By Alice Ly on July 14, 2021
Read time: 7 minutes
MSI applications part 2: peptides and proteins
In this blog post we go back to the roots of mass spectrometry imaging, and describe it’s first breakthrough application on biological samples: analyzing the spatial distribution of proteins and peptides in tissue.
By Alice Ly on August 28, 2021
Read time: 10 minutes
MSI applications part 3: lipids
In this blog post we explore lipid imaging with mass spectrometry, particularly the technical considerations, applications, and limitations.
By Alice Ly on January 12, 2022
Read time: 10 minutes
MSI applications part 4: drugs and small molecule metabolites
In this blog post we look at the use of mass spectrometry imaging for investigating small molecules such as drugs and metabolites and then a quick overview of different metabolomic MSI studies and some challenges facing this area but also tools that can help you with your drug metabolite study.
By Alice Ly on January 20, 2022